Our next Workshop on Quantitative Methods in Education, Health, and the Social Sciences (QMeHSS) will take place on Friday, February 19th, from 11:00am - 12:30pm in NORC conference room 344. Dr. Dylan Small from the University of Pennsylvania will be joining us to lead this workshop, so please join us in giving him a warm welcome and participate in some invigorating discussion. NORC is located at 1155 E. 60th Street. We look forward to seeing you there.
Case Definition and Design Sensitivity in Case Control Studies
Professor, Department of Statistics, The Wharton School, University of Pennsylvania
In a case-control study, cases of a rare outcome are compared to non-cases (called controls in the context of a case-control study) with respect to their antecedent exposure to a treatment in an effort to determine whether exposure causes some cases of the outcome. Cases are typically matched to controls on measured pretreatment covariates. However, in an observational study, there may be unmeasured pretreatment covariates that affect both treatment and outcomes. A sensitivity analysis asks: What magnitude of bias from unmeasured covariates would need to be present to materially alter the conclusions of a naïve analysis that presumes adjustments for measured covariates suffice to remove all bias? The first step in designing a case-control study is to define a case of the outcome and a control. For example, a disease may have different severities and one needs to choose how severe a person’s disease needs to be for the person to be a case. We examine the effects of this design decision on the sensitivity of conclusions to unmeasured biases. We develop an adaptive procedure for choosing the case definition based on the data to make the study as insensitive to unmeasured biases as possible asymptotically. This is joint work with Jing Cheng, Betz Halloran and Paul Rosenbaum.